
Melanotan I (also known as Afamelanotide) is a synthetic linear tridecapeptide analog of alpha-melanocyte stimulating hormone (α-MSH) with greater selectivity for the MC1R melanocortin receptor compared to MT-2. It is studied in preclinical research for MC1R-specific pigmentation biology and melanogenesis pathway investigation. Each batch is verified to ≥99% purity by third-party HPLC. Research Use Only.
Melanotan I is a linear 13-amino-acid peptide analog of α-MSH with preferential MC1R binding affinity. Unlike the cyclic MT-2 (Melanotan 2), Melanotan I demonstrates reduced activity at MC3R, MC4R, and MC5R subtypes, making it the preferred research tool for MC1R-selective studies in melanocyte biology.
Research applications include MC1R-selective pigmentation studies, melanocyte biology, comparative melanocortin pharmacology (Melanotan I vs MT-2 vs α-MSH), eumelanin synthesis pathway research, and photoprotection biology in cell culture models.
Every batch of Melanotan I is synthesized using Solid-Phase Peptide Synthesis (SPPS) and purified via preparative HPLC to eliminate truncated sequences and synthesis byproducts. Final identity confirmation is performed via Electrospray Ionization Mass Spectrometry (ESI-MS), verifying exact molecular weight. Each lot ships with a Certificate of Analysis documenting purity exceeding 99%, giving researchers traceable, batch-specific verification before use in any laboratory protocol.
This product is strictly for research and laboratory use only. It is not approved by the FDA or any global regulatory body for human consumption, veterinary use, or therapeutic application. The purchaser assumes all responsibility for the proper handling, storage, and application of this compound. It must only be handled by qualified professionals in a controlled laboratory setting. By purchasing this product, you agree to abide by all local and international laws regarding the use of research chemicals.

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